The Brilliant Brunette Visibly Brighter In-Shower Lightening Treatment is safe to use on colour-treated and highlighted hair. However, if your hair is intensively bleached or damaged, this hair-lightening product should not be used on your hair. This product works by reacting with and removing melanin from natural hair. If your colour-treated hair is too dark, you may not notice an effect from Brilliant Brunette Visibly Brighter In-Shower Lightening Treatment.